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Public proof of concept

CVE-2024-50636

A public proof of concept exists; no exploitation attested.

  • Published2024-11-11
  • WeaknessCWE-94

Am I affected?

With a domain, we read the version its public headers and pages expose. A distribution build can carry the fix under an older number.

Description

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Timeline

dates in UTC
  1. 2024-11-1123:15CVE publishedNVD

Observed activity

isMalicious corpus · updated 2026-10-23 18:48 UTC
Indicators tagged with this CVE, per day0 indicators over 7 days
Block these indicators
  • Firewall list (EDL, text): https://api.ismalicious.com/edl/cve/CVE-2024-50636?format=txt
  • CSV export: https://api.ismalicious.com/edl/cve/CVE-2024-50636?format=csv
  • TAXII collection of exploited CVEs
  • The EDL and CSV take an API key on the Pro plan.

Versions per branch

CISA-ADP
Schrodinger pymol
BranchAffectedFixed in
2.5= 2.5.0no fix published

as publishedRanges as NVD and OSV publish them; a distribution’s build can be fixed under an older number.

Fix

No fix published by the sources we read yet. NVD record

Detection

Nuclei template
none so far
ProjectDiscovery
Exploit-DB
no entry
Exploit-DB
Proof-of-concept repositories
none listed
PoC-in-GitHub

Sources

Technical details

CVSS v3 Vector
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
Published
2024-11-11
Last Modified
2026-06-17
NVD status
Deferred

Frequently asked questions

What is CVE-2024-50636?

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Is CVE-2024-50636 actively exploited?

A proof-of-concept exploit exists for CVE-2024-50636, but active exploitation has not been confirmed at this time.

What is the CVSS score for CVE-2024-50636?

CVE-2024-50636 has a CVSS v3 base score of 9.8 (CRITICAL severity), with vector string CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H.

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Surveillance reads the versions in your stack — a domain, a lockfile or a list — checks each CVE against the ranges its sources publish, and alerts you when one you run is exploited or enters CISA KEV. A version it cannot read stays « version not verified ».

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